Sekyiwa 'Set' Shakur is Tupac's half-sister.
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Everything You Need To Know About Tupac’s Family Tree
5. Sekyiwa 'Set' Shakur is Tupac's half-sister.
Sekyiwa shared the same mother as Pac and grew up with him in Harlem, New York. Although Tupac referenced her in some of his songs - using the nickname 'Set' - Sekyiwa remains private about her life with her beloved brother, admitting she used to keep her surname a secret to hide her identity.